Download Dendritic Cells in Fundamental and Clinical Immunology: by Ralph M. Steinman, Maggie Pack, Kayo Inaba (auth.), Dr. PDF

By Ralph M. Steinman, Maggie Pack, Kayo Inaba (auth.), Dr. Paola Ricciardi-Castagnoli (eds.)

These complaints comprise chosen contributions from the contributors to the Fourth foreign Symposium on Dendritic cells that was once held in Venice (Lido) Italy, from Oc­ tober five to ten, 1996. The symposium used to be attended through greater than 500 scientists coming from 24 varied nations. reports on dendritic cells (DC) were tremendously hampered by means of the problems in getting ready adequate cellphone numbers and in a cheap natural shape. At this assembly it's been proven that enormous amounts of DC should be generated from precursors in either mice and people, and this danger has tremendously inspired stories aimed to represent DC body structure and DC-specific genes, and to hire DC therapeutically as adjuvants for im­ munization. the opportunity of producing huge numbers of autologous DC that may be utilized in the manipulation of the immune reaction opposed to melanoma and infectious ailments has significantly boosted dendritic mobile learn and the position of DC in a couple of medi­ cal components has been heatedly discussed.

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184: p 53-62, by copyright permission of The Rockefeller University Press. -------------------------~ Figure 3. The induction of KLH'specific T cells in the draining LN of mice injected with DC pulsed with soluble KLH in vitro. Class 11+ CDllc+ spleen cells from Flt3L-treated mice and control DC were pulsed with (+KLH) or without (-KLH) KLH antigen and injected into the foot pads of mice (4 per group). After 7 days, CD4+ T cells were isolated from the popliteal LN draining the foot pads and cultured with freshly isolated control DC in the presence or absence of KLH for 5 days and 3H·thymidine incorporation was measured.

F. 1995. Human blood dendritic cells selectively express CD83. a member of the immunoglobulin superfamily. 1. fmmunol. 154:3821-3835. 4 CD34+ HEMATOPOIETIC PROGENITORS FROM HUMAN CORD BLOOD DIFFERENTIATE ALONG TWO INDEPENDENT DENDRITIC CELL PATHWAYS IN RESPONSE TO GM-CSF+TNFn C. Caux,l c. Massacrier,l B. Vanbervliet,l B. Dubois,l B. de Saint-Vis,l C. Dezutter-Dambuyant/ C. Jacquet,2 D. Schmitt,2 and J. Banchereau l ISchering-Plough Laboratory for Immunological Research Dardilly, France 2INSERM U346 Hopital Edouard Herriot Lyon.

Celona. A. Cohn. 1992. Novel responses of human skin to intradermal recombinant granulocyte/macrophage-colony-stimulating factor: Langerhans cell recruitment. keratinocyte growth and enhanced wound healing. 1. Exp. Med. 175: 1717-1728. 19. Larsen CP, Morris PJ, Austyn JM (1990 a) Migration of dendritic leukocytes from cardiac allografts into host spleens: A novel pathway for initiation of rejection. J. Exp. Med. 171:307-314 20. Larsen CPo Steinman RM. Witmer-Pack M, Hankins DF. Morris PJ, and Austyn JM (1990 h) Migration and maturation of Langerhans cells in skin transplants and explants.

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