Download Biomembranes: Structural and Functional Aspects by Meir Shinitzky PDF
By Meir Shinitzky
An up-to date evaluation of simple examine on biomembranes. during this quantity, top-rated specialists within the box reflect on an important structural and useful elements of biomembranes: - Membrane Lipids and Aging
- Membrane-bound Enzymes
- Ion Channels in organic Membranes
- Anion Exchangers of Mammalian cellphone Membranes
- range of delivery Mechanisms in Bacteria.
the quantity is a wonderful complement to 'Biomembranes - actual Aspects', additionally edited via Meir Shinitzky. jointly those books supply a entire flooring for realizing advanced physiological processes.
Meir Shinitzky, Ph.D., is a Professor of Biophysics within the division of Membrane learn and Biophysics, The Weizmann Institute of technology, Rehovot, Israel. considering that 1971, his study has all in favour of a variety of features of membrane constitution and dynamics. at the moment his major curiosity is in manipulation of membrane fluidity for medical diagnoses and coverings. He has released widely and is said around the world as one of many top specialists within the more and more major box of biomembrane learn.
Chapter 1 Membrane Lipids and getting older (pages 1–82): Hilary R. Shmeeda, Elisabeth B. Golden and Yechexkel Barenholz
Chapter 2 Membrane?Bound Enzymes (pages 83–197): G. Lenaz and M. Degli Esposti
Chapter three Ion Channels in organic Membranes – common ideas (pages 199–296): Rami Rahamimoff, Simona Ginsburg, Gavriel Barkai, Boaz prepare dinner, Jackie Edry?Schiller, Igor Kaiserman, Alon Meir, Michal Roll, Mary Kate Worden and Nilly Yakir
Chapter four Anion Exchangers of Mammalian phone Membranes (pages 297–327): Z. Ioav Cabantchik
Chapter five variety of shipping Mechanisms in micro organism (pages 329–379): Bert Poolman, Douwe Molenaar and Wil N. Konings
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Extra resources for Biomembranes: Structural and Functional Aspects
It is possible to envisage that deviations from the optimal lipid composition may lead to the exclusion of undesirable lipids from areas of important enzyme function or the storage of excess or undesirable lipids. Metabolic Aspects of Age-Related Alterations in Membrane Lipid Composition Phospholipids Very few studies have addressed the changes that may take place in lipid composition as a function of aging at the metabolic level. Changes in rates of biosynthesis or degradation, altered transfer rates in and out of the cell, changes in the activity of lipid exchange proteins and changes in post-transfer modification or processing may lead to the observed age-related alterations in lipid composition (Fig.
In contrast, Tabata et al.  examined the incorporation of plasma palmitate in different regions of rat brain at 3, 12, 24 and 34 month of age and found no significant changes suggesting that lipid turnover in the brain does not change significantly. Martinez et al.  studied the fatty acid composition of human retina during development. They found an increase in 22:6 w3, 2 2 5 w3, Membrane Lipids and Aging 29 20:3 0 6 and 20:4 06. Rotstein et al. [351J has studied the effects of aging on the composition of decosahexaenoate (22:6) containing lipids in rat retina in 2-3 month vs.
They compared adrenal glands H. R. Shmeeda 34 el al. TABLE II Changes in cholesterol metabolism with aging System Age Metabolic change Rat liver 5 weeks9 months Mevalonate incorporation into sterol (-)  Serum chol levels (+I Diurnal flux of HMG-CoA reductase (+) Chol-7a hydroxylase activity (-) Hepatic acyl-CoA: Chol acyltransferase (0) Acetoacetyl-CoA thiolase activity (-) Acetoacetyl-CoA synthetase activity ( -) HMG-CoA synthase activity (-1 HMG-CoA reductase activity (-1 Mevalonate kinase activity (-1 Rat adrenal gland 2-18 months Chol esters (+I [3241 I4c-acetate incorporation (-> HMG-CoA reductase (-1 Acyl-CoA: Chol acyltransferase activitfl -) Acetoacetyl CoA thiolase activity (0) HMG-CoA synthetase activity (0) Mevalonate kinase activity (-1 2-12 months Ref.