Download Basic Immunology: Functions and Disorders of the Immune by Abul K. Abbas MBBS, Andrew H. H. Lichtman MD PhD, Shiv PDF

By Abul K. Abbas MBBS, Andrew H. H. Lichtman MD PhD, Shiv Pillai MBBS PhD

In this up-to-date version of Basic Immunology, the authors proceed to convey a transparent, sleek creation to immunology, making this the most obvious selection for today’s busy scholars. Their adventure as academics, direction administrators, and teachers is helping them to distill the middle info required to appreciate this advanced box. by using high-quality illustrations, relevant medical situations, and concise, targeted text, it’s a superbly accessible advent to the workings of the human immune process, with an emphasis on medical relevance.

  • Concise, clinically centred content is logically organized by way of mechanism for effective mastery of the material.
  • Features an appendix of scientific cases and CD molecules.
  • Includes numerous full-color illustrations, precious tables, and chapter outlines.
  • Focus questions within every one bankruptcy are perfect for self-assessment and review.
  • Key points bolded during the textual content make it effortless to find vital information.
  • Presents info in a layout and elegance that maximizes usefulness to scholars and teachers learning drugs, allied wellbeing and fitness fields, and biology.
  • Fully up-to-date content equips you with the newest correct advances in immunology.
  • Revised and updated artwork complements your visible studying of significant ideas and decreases the over the top real information present in higher textbooks.
  • Twelve brand-new animations to be had on Student Consult aid additional clarify complicated concepts.
  • Student seek advice booklet model incorporated with buy. This more advantageous book event gives you entry to the textual content, figures, pictures, thesaurus of immunology phrases, self-assessment questions, and references on various units.

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Extra resources for Basic Immunology: Functions and Disorders of the Immune System

Sample text

Some polymorphisms of the NOD2 gene are associated with inflammatory bowel disease; the underlying mechanisms remain poorly understood. • NLRP-3 (NOD-like receptor family, pyrin domain containing 3) is a cytosolic NLR that responds to many unrelated microbial struc- tures or pathologic changes in the cytosol and reacts by enhancing production mainly of the inflammatory cytokine IL-1β. It contains an Nterminal pyrin domain (so named because it is present in receptors that induce the production of fever-causing cytokines; Greek, pyro meaning burn).

The cells and molecules that are responsible for innate immunity make up the innate immune system. Innate immunity is the critical first step in host defense against infections. It blocks microbial invasion through epithelial barriers, destroys many microbes that do enter the body, and is capable of controlling and even eradicating infections. The innate immune response is able to combat microbes immediately upon infection; in contrast, the adaptive immune response needs to be induced by antigen and therefore is delayed.

TLR-2 recognizes several bacterial and parasitic glycolipids and peptidoglycans; TLR-3, -7, and -8 are specific for viral singlestranded and double-stranded RNAs; TLR-4 is specific for bacterial LPS (endotoxin); TLR-5 is specific for a bacterial flagellar protein called flagellin; and TLR-9 recognizes unmethylated CpG DNA, which is more abundant in microbial genomes than in mammalian DNA. TLRs specific for microbial proteins, lipids, and polysaccharides (many of which are present in bacterial cell walls) are located on cell surfaces, where they recognize these products of extracellular microbes.

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