Download Applying Quantitative Bias Analysis to Epidemiologic Data by Timothy L. Lash PDF

By Timothy L. Lash

This textual content presents the first-ever compilation of bias research tools to be used with epidemiologic info. It courses the reader in the course of the making plans levels of bias research, together with the layout of validation reports and the gathering of validity facts from different assets. 3 chapters current equipment for corrections to handle choice bias, out of control confounding, and class blunders. next chapters expand those how to multidimensional bias research, probabilistic bias research, and a number of bias research. The textual content concludes with a bankruptcy on presentation and interpretation of bias research results.

Although ideas for bias research were on hand for many years, those equipment are thought of tough to enforce. this article not just gathers the tools into one cohesive and arranged presentation, it additionally explains the equipment in a constant model and offers customizable spreadsheets to enforce the suggestions. via downloading the spreadsheets (available at hyperlinks supplied within the text), readers can stick to the examples within the textual content after which alter the spreadsheet to accomplish their very own bias analyses. Readers with no adventure utilizing quantitative bias research can be capable of layout, enforce, and comprehend bias analyses that deal with the most important threats to the validity of epidemiologic examine. more matured analysts will price the compilation of bias research equipment and hyperlinks to software program instruments that facilitate their projects.

Timothy L. Lash is an affiliate Professor of Epidemiology and Matthew P. Fox is an Assistant Professor within the middle for overseas overall healthiness and improvement, either on the Boston collage tuition of Public healthiness. Aliza ok. Fink is a undertaking supervisor at Macro foreign in Bethesda, Maryland. jointly they've got prepared and awarded many day-long workshops at the equipment of quantitative bias research. furthermore, they've got collaborated on many papers that built tools of quantitative bias research or used the tools within the facts research.

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Extra info for Applying Quantitative Bias Analysis to Epidemiologic Data

Sample text

If the pooled risk ratio is substantially different from crude risk ratio, then the pooled risk ratio will provide an estimate of association that is unconfounded (by age) and is precision enhancing, in that its confidence interval will be narrower than those obtained from alternative methods for averaging the risk ratio across strata of age. Pooling reduces both the random error (by yielding a precision-enhancing estimate of association) and the systematic error (by yielding an estimate of association unconfounded by age).

When a wider interval is obtained, inference from the study’s results should be tenuous because of the substantial random error, regardless of whether systematic error has also been estimated quantitatively. Note that this formulation assumes that investigators use conventional confidence intervals as intended, that is, as a measure of error. Investigators who simply note whether the interval includes the null, a surrogate for statistical significance testing, will often be mislead by statistically significant, but substantially imprecise estimates of association (Poole, 2001).

The investigator should plan such studies at the outset, should allocate study resources to the data collection effort, and should assure that the validation substudy is completed with the same rigor as applied to the principal study. Creating an Analytic Plan for a Bias Analysis Valid epidemiologic data analysis should begin with an analytic strategy that includes plans for quantitative bias analysis at the outset. The plan for quantitative bias analysis should make the best use of the validation data collected per the design described above.

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