Download Antibody Fc. Linking Adaptive and Innate Immunity by Margaret Ackerman, Falk Nimmerjahn PDF

By Margaret Ackerman, Falk Nimmerjahn

Antibody Fc is the 1st unmarried textual content to synthesize the literature at the mechanisms underlying the dramatic variability of antibodies to persuade the immune reaction. The booklet demonstrates the significance of the Fc area, together with protecting mechanisms, effector mobilephone varieties, genetic info, and variability in Fc area functionality. This quantity is a serious single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers in addition to graduate scholars in immunology and vaccinology.

Antibodies characterize the correlate of safety for varied vaccines and are the main quickly becoming category of substances, with functions starting from melanoma and infectious sickness to autoimmunity. Researchers have lengthy understood the variable area of antibodies, that are chargeable for antigen popularity, and will supply defense through blocking off the functionality in their objective antigen. besides the fact that, contemporary advancements in our knowing of the safety mediated by way of antibodies have highlighted the serious nature of the antibody consistent, or Fc area, within the organic job of antibodies. The Fc area permits antibodies to hyperlink the adaptive and innate immune platforms, offering specificity to quite a lot of innate effector cells. furthermore, they supply a suggestions loop to control the nature of the immune reaction through interactions with B cells and antigen-presenting cells.

  • Clarifies the several mechanisms of IgG job on the point of different version platforms used, together with human genetic, mouse, and in vitro
  • Covers the position of antibodies in melanoma, infectious ailment, and autoimmunity and within the environment of monoclonal antibody remedy in addition to certainly raised antibodies
  • Color illustrations increase reasons of the immune system

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Additional info for Antibody Fc. Linking Adaptive and Innate Immunity

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Petroni KC, Shen L, Guyre PM. Modulation of human polymorphonuclear leukocyte IgG Fc receptors and Fc receptor-mediated functions by IFN-γ and glucocorticoids. J Immunol 1988;140(10):3467–72. Rivas-Fuentes S, Garcia-Garcia E, Nieto-Castaneda G, Rosales C. Fcγ receptors exhibit different phagocytosis potential in human neutrophils. Cell Immunol 2010;263(1):114–21. Marois L, Vaillancourt M, Marois S, Proulx S, Pare G, Rollet-Labelle E, et al. The ubiquitin ligase c-Cbl down-regulates FcγRIIa activation in human neutrophils.

Castellano F, Montcourrier P, Chavrier P. Membrane recruitment of Rac1 triggers phagocytosis. J Cell Sci 2000;113(Pt 17):2955–61. Castellano F, Montcourrier P, Guillemot JC, Gouin E, Machesky L, Cossart P, et al. Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formation. Curr Biol 1999;9(7):351–60. Zhang Q, Cox D, Tseng CC, Donaldson JG, Greenberg S. A requirement for ARF6 in Fcγ receptor-mediated phagocytosis in macrophages. J Biol Chem 1998;273(32):19977–81.

While very little is known about the exact intracellular fate of opsonized virus particles and how this relates to their infectivity in phagocytes, most available data indicate that FcR-mediated uptake into phagocytes does not interfere with intracellular viral replication. However, in situations when opsonizing antibodies have direct neutralizing effects on the fusion or uncoating process of the virus, and when this property is maintained under acidic conditions as present in late phagosomes/lysosomes,106–108 FcR-mediated uptake of opsonized viruses might restrict replication within phagocytes.

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