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By John J. Langone (Eds.)

The severely acclaimed laboratory average, Methods in Enzymology, is among the such a lot hugely revered guides within the box of biochemistry. given that 1955, every one quantity has been eagerly awaited, usually consulted, and praised by means of researchers and reviewers alike. The sequence includes a lot fabric nonetheless correct this day - really an important e-book for researchers in all fields of existence sciences

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Antibodies, Antigens, and Molecular Mimicry

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Nepom, K. A. Nelson, S. L. Holbeck, I. Hellstrrm, and K. E. HeUstrrm, Proc. Natl. Acad. Sci. A. 81, 2864 (1984). [1] IDIOTYPIC NETWORKS AND MOLECULAR MIMICRY 17 the advantage of not being genetically restricted. 95 Internal image idiotypes mimic the three-dimensional shapes of antigens and thus are effective across the species barrier. At the same time, antigen can be presented in a different molecular environment. The other method of using the idiotype network rests on the existence of so-called regulatory idiotypes, 25,96,97 which may also be linked to the regulatory network of anticancer responses.

Gall, P. D. Gottlieb, U. Rutishauser, and M. J. Waxdal, Proc. Natl. Acad. Sci. A. 63, 78 (1969). ~46F. W. Putnam, A. Shimizu, C. Paul, T. Shinoda, and H. K6hler, Ann. Y. Acad. Sci. 190, 83 (1971). i47 R. J. Polljak, L. M. Amzel, H. P. Avey, B. L. Chen, R. P. Phizackerley, and F. San, Nature (London) 245, 165 (1973). 148 E. A. Padlan, D. Segal, T. F. Spande, and D. R. Davies, Proc. Natl. Acad. Sci. A. 69, 3689 (1972). ~49j. UrbaJn, M. Wikler, J. D. Franssen, and C. Collignon, Proc. Natl. Acad. Sci.

A. Velente, P. Laccetti, C. Marcocci, M. De Luca, P. Ealey, N. J. Marshall, and E. F. Groliman, in "Monoclonal and Anti-Idiotypic Antibodies: Probes for Receptor Structure and Function" (J. C. Venter, C. M. Fraser, and J. ), Vol. 4, p. 85. Liss, New York, 1984. 133T. Kieber-Emmons and H. K6hler, lmmunol. Rev. 90, 29 (1986). 134T. Kieber-Emmons, E. Getzoff, and H. K6hler, Int. Reo. lmmunol. 2, 339 (1987). 135 p. M. Coleman, G. M. Air, R. G. Webster, J. N. Vargehese, A. T. Baker, M. R. Leutz, P. A.

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