Download AID for Immunoglobulin Diversity by Frederick W. Alt PDF

By Frederick W. Alt

Advances in Immunology, a protracted tested and hugely revered serial, offers present advancements in addition to entire stories in immunology. Articles deal with the big variety of subject matters that contain immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and medical modalities. Edited and authored by way of the major scientists within the box, every one quantity offers updated details and instructions for destiny study.

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Conticello, Marc‐Andre Langlois, Zizhen Yang, and Michael S. Neuberger Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom 1. 2. 3. 4. 5. 6. 7. 8. 9. Abstract .................................................................................................................... Introduction .............................................................................................................. AID: The DNA Deaminase Trigger for Antibody Diversification .....................................

Biol. Chem. 272, 6561–6566. , and Honjo, T. (1996). High frequency class switching of an IgMþ B lymphoma clone CH12F3 to IgAþ cells. Int. Immunol. 8, 193–201. , Lee, C. , and Shimizu, A. (2003). Transcription‐coupled events associating with immunoglobulin switch region chromatin. Science 302, 2137–2140. , and Scott, J. (1998). Escherichia coli cytidine deaminase provides a molecular model for ApoB RNA editing and a mechanism for RNA substrate recognition. J. Mol. Biol. 275, 695–714. 34 M A S A M I C H I M U R A M AT S U E T A L .

Acad. Sci. USA 101, 1975–1980. , Mol, C. , Arvai, A. , Peterson, S. , Tainer, J. , and Krokan, H. E. (1996). Excision of cytosine and thymine from DNA by mutants of human uracil‐DNA glycosylase. EMBO J. 15, 3442–3447. 32 M A S A M I C H I M U R A M AT S U E T A L . , Liabakk, N. , Krokan, H. , and Slupphaug, G. (2005). B cells from hyper‐IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil. J. Exp. Med. 201, 2011–2021. , Lee, C. , and Honjo, T.

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