Download Adverse Reactions to Non-Steroidal Anti-Inflammatory Drugs: by B.-E. Wiholm (auth.), Dr. Michael Kurowski (eds.) PDF
By B.-E. Wiholm (auth.), Dr. Michael Kurowski (eds.)
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J. Am. Med. Assn . 243: 661 (1980). 20. Persantine-Aspirin Reinfarction Study Research Group, Persantine and aspirin in coronary heart disease. Circulation 62: 449 (1980). 21. Steering Committee of the Physicians' Health Study Research Group, Final report on the aspirin component of the ongoing Physicians' Health Study. N. Eng\. J. Med . 321 : 129 (1989). 22 . , Nonsteroidal anti-inflammatorydrugs and bleeding peptic ulcer. Lancet, i, 462 (1986). 23. , and Schaffner, W, Non-steroidal anti-inflammatory drug use and death from peptic ulcer in elderly persons.
Drug utilization in relation to morbidity. Acta Med. , suppl. 721 , 1-35 (1988) . 7. , Differences in national drug-prescribing pattern s. Clinical pharrnacological evaluation in drug contro!. Report on a World Health Organization Symposium, Deidesheim , Germany, 11-14 November 1975. World Health Organization Regional Office for Europe, Copenhagen 1976, pp. 19-47. 8. , and Westerho1m, B. ) , Studies in drug utilization: methods and applications. World Health Organization Regional Office for Europe, Publication Serono.
2). This fact may not have been fully appreciated when an apparently excessive number of ADRs were received by ADR committees and substantiated clinically by gastroenterologists . The ensuing uproar caused sales of Feldene to plummet dramatically. This led to Pfizer's undertaking a multicenter double-blind phase IV study to compare Naprosyn and Feldene vis- ä-vis efficacy and safety in a cohort of 2,035 patients suffering from osteoarthritis, aged 17 years and upwards, recruited from the general population .